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Specialized Programs of Research Excellence (SPORE) Grant Projects UCSF Brain Tumor SPORE Principal Investigator: Mitchel S. Berger MD Clinical Science Principal Investigator: Susan Chang MD Basic Science Principal Investigator: Russell O. P50: SPECIALIZED/RESEARCH CENTER GRANTS Research Center Grants serve varying scientific and IC-specific purposes. A Specialized Program of Research Excellence (SPORE) must provide focal points for sustaining and maintaining state-of-the-art. Each applicant institution may submit multiple SPORE applications provided that they are scientifically distinct, proposed in a different cancer organ site and are led by different PDs/PIs. A single investigator may participate in more than one SPORE as long as there is no scientific overlap. Displays the number and dollar amount of P50 and co-funded SPOREs. In 1992, the NCI established the Specialized Programs of Research Excellence (SPORE). The NCI Translational Research Program (TRP) is the home of the SPOREs, and a cornerstone of. UCLA's Jonsson Comprehensive Cancer Center and the department of urology at the David Geffen School of Medicine at UCLA have been notified that their standing as a National Cancer Institute Specialized Program of Research Excellence (SPORE) site in prostate cancer has been renewed for another five. Breast Cancer SPORESpecialized Program of Research Excellence (SPORE) in Breast Cancer. The University of Chicago Specialized Program of Research Excellence (SPORE) in Breast Cancer brings together a multidisciplinary team of basic, clinical, and population science investigators to design innovative research and use a global strategy to reduce worldwide suffering from breast cancer. Our program is 1 of only 1. NCI Breast Cancer SPOREs in the United States. The UChicago Breast Cancer SPORE aims to develop genetic and imaging- based approaches to the prevention, detection, and treatment of breast cancer in women who are at increased risk of developing an aggressive form of malignancy at a young age. Researchers at the University of Iowa Holden Comprehensive Cancer Center have received a five-year, $10.67 million Specialized Programs of Research Excellence (SPORE) grant to study neuroendocrine tumors. This is the first and only SPORE grant ever awarded. Since this type of breast cancer disproportionately affects young women of African ancestry, a portion of the Breast SPORE tackles the global issue of health disparities among various ethnic and racial groups. The Breast Cancer SPORE comprises four primary research projects, which are supported by three resource cores. In addition, the Developmental Research Program and the Career Development Program promote novel research endeavors and provide support for young investigators at the University of Chicago. Cox, Ph. D, Peter Hulick, MD, Katharine Yao, MDHypothesis: We hypothesize that genomic markers influence breast cancer risk, and population- specific Polygenic Risk Score (PRS) can be used to stratify diverse populations of women into risk categories and that provision of informationregarding complex genetic risks will positively influence behavior and cancer prevention activities. Specific Aim 1: Evaluate the performance of PRS in clinically defined cohorts of high- risk women. Guidelines for NCI SPORE Grants September 2012 iii FOREWORD Specialized Programs of Research Excellence (SPOREs) are specialized center grants to support multi-project, interdisciplinary, and in some cases, multi-institutional, translational research. SPOREs - the Specialized Programs of Research Excellence - are a cornerstone of the National Cancer Institute's efforts to promote collaborative, interdisciplinary translational cancer research. SPORE grants involve both basic and clinical scientists and support. Specific Aim 2: Assess stakeholder (patient and provider) preferences, and evaluate the risks and benefits of communicating Complex Personalized Cancer Risk Profiles to ethnically diverse high- risk patients. Project 2: Targeting Heat Shock Protein 9. Client Proteins in Triple Negative Breast Cancer. Project Leaders: Suzanne Conzen, MD, Olufunmilayo I. Olopade, MBBS, Rita Nanda, MDCo- Investigators: Gini Fleming, MD, Nora Jaskowiak, MDHypothesis: We hypothesize that inactivating the Hsp. GR/SGK1 and JAK will increase TNBC chemotherapy sensitivity and tumor responsiveness. Specific Aim 1: Determine if inactivation of the GR/SGK1 pathway mediates Hsp. TNBC tumor cell death. Researchers at the University of Iowa Holden Comprehensive Cancer Center have received the first-ever Specialized Programs of Research Excellence (SPORE) grant to study neuroendocrine tumors. SPORE grants are funded through the National Cancer Institute. NEUROENDOCRINE TUMOR (NET) SPECIALIZED PROGRAM OF RESEARCH EXCELLENCE (SPORE) 2016 DEVELOPMENTAL RESEARCH FUNDING OPPORTUNITY University of Iowa Letter of Concept Deadline: Monday, August 1, 2016 Invited Full. Specific Aim 2: Determine if inactivation of the JAK/STAT pathway mediates Hsp. TNBC tumor cell death. Specific Aim 3: Determine whether GR/SGK1 and/or JAK/STAT3 expression in TNBC decreases following neoadjuvant treatment with an Hsp. Project 3: Mechanisms of Immune Evasion in Breast Cancer. Project Leaders: Yang- Xin Fu, MD, Ph. D, Rita Nanda, MDCo- investigators: Thomas Gajewski, MD, Ph. DHypothesis: We hypothesize that anti- PD- L1 can overcome Ab- resistance and lead to tumor regression. Specific Aim 1: Determine if and how anti- PD- L1 antibody synergizes with anti- neu antibody treatment. Specific Aim 2: Understand the role that PD- L1 upregulation plays in response to trastuzumab- based therapy in patients with HER2- amplified breast cancer. Project 4: Pharmacogenomics of Breast Cancer Therapies. Project Leaders: M. Cox, Ph. D, Douglas Merkel, MD, Mark Ratain, MDHypothesis: We hypothesize that germline genetic variation accounts for a significant proportion of the inter- individual variability in the toxicity of chemotherapy agents used in breast cancer therapy, and that provision of information regardinggenetic risks for toxicity to clinicians will alter and increase the chemotherapy treatment choices for patients. Specific Aim 1: Identify a set of SNPs associated with capecitabine and paclitaxel toxicity in preclinical models, including characterization of these variants using pre- clinical functional studies. Specific Aim 2: Use five large sets of clinical samples from breast cancer patients treated with paclitaxel or capecitabine to: a) validate LCL toxicity associated SNPs from Aim 1; b) identify novel genetic variants associated with paclitaxel- or capecitabine- related toxicity, and; c) build multigenic predictive models associated with sensitivity to paclitaxel and capecitabine. Specific Aim 3: Translate well- characterized variants from the above clinical studies of breast cancer pharmacogenomics into a clinical, preemptive testing treatment approach for breast cancer patients. Sequential Query Language Database Networking Using SQL Sequential query language (SQL) is used in combination with a SQL database server to store and access data over large networks quickly. SQL (pronounced 'ess-que-el') stands for Structured Query Language. SQL is used to communicate with a database. According to ANSI (American National Standards Institute), it is the standard language for relational. 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C library function ctime() - Learn C programming language with examples using this C standard library covering all the built-in functions. All the C functions, constants and header files have been explained in detail using. The first three do in the ways I'm aware of declare that the std is to be used. The fourth function simply calls time() - which to me seems like either one of the < time. Question 1: Why doesn't this (function. Question 2: Which variant is used and what determines that one takes precedence over the other? Question 3: Is there a way to, say, output the function name in its entirety during a run or compilation process to see what library is used? GameDev.net is a platform for game. CTime will cease working in. C Date and time utilities. C-style date and time utilities. Functions: Time manipulation: difftime. There are many more time functions than we consider here. Write a C program to produce a series of floating point random numbers in the ranges (a). DOCUMENTATION: How to convert the ctime of directory names and backup IDs to. This time can be converted to a human readable format by using the bpdbm binary on the. C:\Program Files\VERITAS\NetBackup\bin>bpdbm. IPC:Message Queues:<sys/msg.h> Subsections. The message queue must be initialised with the msgget.c program. Program utilities: Variadic function support. Retrieved from 'http:// Navigation.The newly launched NSW rural generalist training program has been described as. NSW rural generalist pathway launched. Rural GP Procedural Training Program. The program provides opportunities for GPs / GP Registrars to acquire additional skills in procedural general practice that equips them to practice in rural NSW. Background NSW Health funds 30FTE rural procedural GP training positions per year under the Rural NSW GP Procedural Training Program in NSW The New England region has a sound history of GP procedural training 14 ARSPs are. Through either of two programs: . NSW Rural GP Procedural. RDN - Pre- Vocational Doctors. Jump to: General Practice Training Program On graduating from a medical degree at university, a Junior Medical Officer (JMO) must progress through an internship (including hospital training) and early Post- Graduate Years (PGY 1 and 2) to then make a decision about future training and specialisation (PGY 3 and beyond). If you are a junior doctor unsure of the career progression of a General Practitioner, please view this chart outlining the steps involved in becoming a GP. If you are undecided about your future, working as a Rural GP is an option available to you. The GP Training Program is flexible and even allows you to train part time. The Federal Government recently announced there will be an additional 3. The Rural Generalist (RG) program. NSW Rural GP Procedural Training (GPPT) program In the Rural GP Procedural Training (GPPT) program, doctors can undertake advanced skills training in obstetrics and gynaecology, anaesthesia. NSW Rural Generalist Program The NSW Rural Generalist Training Program is an initiative. NSW Rural Generalist Program. The NSW Rural Generalist Training. Departments and to provide procedural services. GP training places across Australia for 2. Who can apply? To ensure you are eligible to apply for the General Practice Training Program (GP training), please visit the AGPT website and complete the eligibility flowchart. When to apply? Applicants can apply as early as from their intern year. Applicants in later stages of training/employment may be eligible to apply for Recognition of Prior Learning (RPL) for their hospital- based GP training component. How to apply? All applications for GP training are to be made to AGPT. When you make your application to GP training you are required to nominate which Regional Training Provider (RTP) to whom you would like to apply to undertake the Australian General Practice Training (AGPT) program. There are seven RTPs located in New South Wales. Each of these training providers offer comprehensive education and training programs and quality in- practice supervision to equip GP registrars with the skills required to become independent GPs. Application dates and process GP Procedural Training Program. Applications for the GP Procedural Training (GPPT) positions in Hunter New England (Tamworth & Armidale) are now open and close 27 November. Please visit the NSW. Securing a Stable Medical Workforce for NSW Rural Communities NSW HEALTH PAGE 1 SECTION 1 Contents Background.2 NSW Initiatives Targeted Towards Recruitment of. Whilst the NSW GP Procedural Training program has. Training grants; Courses. This one and half day Active Learning Module developed by RACGP NSW&ACT, aims to develop and enhance GP skills in. Clinical Emergency Management Program (CEMP) RACGP events and courses; ACT. Back to top. Rural General Practice Training Pathway Applicants to GP training can apply for either a general or rural pathway, the main difference being where the majority of training is completed. The rural pathway is the right choice if you want to work in rural and remote New South Wales. The rural pathway is for registrars wishing to undertake their training in rural areas. In a rural pathway, GP Registrars are required to complete a minimum of 1. GP term training in regional or rural locations (RA 2- 5 areas) and are eligible for generous government financial incentives. Overseas Trained Doctors (OTDs) affected by the 1. Back to top. NSW Regional Training Organisations. Following the Federal Government restructure of the Regional Training Provider (RTP) network and a competitive tendering process, in 2. GP Synergy was appointed to deliver training in regional NSW. Phone: 1. 30. 0 4. Successful applicants will enter Rural Generalist Training at PGY 2. The first intake of PGY 2 and 3 doctors for this program was in 2. Lateral entry to the program is possible if there are vacant advanced skills training positions. Networking and support is provided for trainees to have an integrated training plan utilising advanced skills within Local Health Districts, and to assist in sourcing employment and career options based on workforce need post program. Network activities include workshops/skills sessions, e- chat forums, teleconference meetings, teletutorials and career planning. For more information on the Rural Generalist Training Program, go to the Health Education and Training Institute website. Back to top. Alternative pathways into rural General Practice - Rural Locum Relief Program (RLRP) Prevocational programs provide excellent opportunities for junior doctors to interact with experienced rural medical doctor mentors. If you are Australian trained or have passed your Australian Medical Council (AMC) exams and are completing your second postgraduate year, you can try a rotation as a Rural GP (and be paid for it!) by participating in the NSW Rural Doctors Network Rural Locum Relief Program (RLRP). To find out more email RDN or call 0. Back to top. Useful Web Links Back to top. Should We License Parenting? In reading the brilliant book The Anatomy of Violence by Adrian Raine, the subject of licensing parenting is brought up near the end. It’s a good old debating topic that often provokes strong opinions. Should parenting require. Some claim that giving birth is a fundamental human right and everyone is entitled to it. Of course, this is not so obvious: What are human rights and in what way do they exist? You see, human rights are abstract objects, and, as a conceptual nominalist, I would argue that they only exist in the human mind. Thus, in any real sense, human rights only exist in a mind independent manner when codified into a law or laws. And these will vary throughout the world. So, really, human rights are simply moral codes derived from moral philosophy, and the application of logical argument. Libertarianism and Parental Licensing.Not only are human rights not ontically real, but if you argue that they conceptually or even objectively exist, there is a lot of work to be done in asserting which ones are valid, and which ones aren’t. Things get complicated when vying for rights. Let’s imagine I live in a community where all resources are allocated – there is no spare capacity for any more humans. Surely I could argue that your right to give birth to a child impinges on my right (or my already existing children’s rights) to life (clean water, food etc.)? What about when there are spare resources? Your child still takes away resources form my family. Rights are tricky. Nature already denies many people the ability to have children. How does this interact with the notion of human rights? We already strictly regulate parenting in the fostering and adoption spheres. So for those people in (3) who cannot have children (or choose adoption), we make them jump through hoops to actually parent. This is the adoption assessment section from the UK government website: 3. Adoption assessment. Once the agency gets your application it will do the following: Invite you to a series of preparation classes – these are normally held locally and give advice on the effect adoption may have on you.
Arrange for a social worker to visit you on several occasions to carry out an assessment – this is to check you’re suitable to become an adoptive parent. Arrange a police check – you will not be allowed to adopt if you, or an adult member of your family, have been convicted of a serious offence, eg against a child. Ask you to provide the names of 3 referees who will give you a personal reference. One of your referees can be a relative. Arrange for you to have a full medical examination. Your assessment. The social worker will send the assessment report to an independent adoption panel. This is a group of people who are experienced in adoption. The panel will make a recommendation to the adoption agency based on your assessment. You can go along to ask questions and answer any questions the panel has. The adoption panel will send their recommendation to the agency, which will then decide whether you’re suitable to adopt a child. If you can adopt a child. Once your agency decides you can adopt, they’ll begin the process of finding a child for you to adopt. Your agency will refer you to either the: They’ll do this immediately or 3 months after you’ve been approved to adopt if they’re not actively considering a local match with a child. The registers hold details of children across England and Wales who need adopting. Let me dwell on this fourth point a little. There are strict guidelines, and regulatory structures and processes in place to ensure that the child gets the best, most secure parenting they can, or at least a high minimum requirement. This appears to be a rather obvious example of double standards, certainly if one agrees to this practice, and yet argues that regular childbirth and parenting should be an unregulated human right. We know that the biosocial jigsaw, as Raine would say, is a complex interaction of genes, biology and environment. The adoption process tries to mitigate the known risk factors through regulation (read licensing). This, then, lessens the damage done to children that, in turn, lessens the damage and cost to society. Now, I am not saying we should license parenting here, per se. But I am questioning whether it is not a bad idea, especially since we already do this to people who are unfortunate enough not to be able to have children, or who want to help others, and choose or have to go through the adoption process in order to have children. For more information on the massive array of damage you can do to children in the long and short term, please read Raine’s excellent book. Chris Pirillo, flickr. Stay in touch with A Tippling Philosopher on Facebook. Should we license parents? Society seems to value kids, yet we aren’t doing much to help raise them well. It’s clear the efforts to make divorce harder for those couples with minor children isn’t going to work and who knows if making marriage harder would work either. But maybe it isn’t about marriage at all. Maybe it’s about creating the best society in which to raise kids. And maybe we’re not doing that right. The New York Times highlighted some interesting parenting arrangements with its recent article, Making a Child, Minus the Couple. Gays and lesbians have been creating parenting partnerships for years, but recently, numerous social networks have sprung up to match prospective parent to prospective parent, hetero and/or gay — a decidedly odd twist to online dating sites. Dating and love don’t factor into it at all, nor does sex. It’s all about those people who want to have a baby and want someone — anyone — to help them raise that baby. But, where’s the love, you might be wondering? As some people have noted, trying to raise kids in a relationship based on love is problematic. After all, love comes and goes. Maybe not.“Certainly, from a research standpoint, I don’t think having a romantic relationship is necessary to have a good co- parenting relationship. Research shows that if parents can have a warm, cooperative, co- parenting relationship, then that’s going to be positive for the child’s development,” says Sarah Schoppe- Sullivan, an associate professor in the Ohio State University department of human sciences. Of course, most of us don’t think of raising a baby from a “research standpoint.”Others laud how parenting partnerships get people to focus on the realities of child- rearing early, way before junior is born. As Jennifer Chrisler, executive director of Family Equality Council, notes: That level of thoughtfulness really benefits kids — these are people who have thought about how do I want to raise a child, whom do I want to raise a child with — that can only be good for children. We should all think that hard about how we are going to have our kids and what we’re going to do once they’re in the world. If everybody gave that kind of thought to having children, we’d probably have better outcomes. Maybe we should legislate that kind of thoughtfulness. But more on that shortly. It’s clear that as a society we’re becoming much more accepting of different ways in which to raise kids. Some 4. 0 percent of first babies born today are to single moms, many of whom are cohabiting. And fewer people say having children is a “very important reason to get married,” a recent Pew study indicates. So, do we even need to be married to have kids? No, according to Judith Stacey, sociology professor at New York University and author of Unhitched: Love, Marriage, and Family Values from West Hollywood to Western China. Marriage “is not a universal, necessary, or intrinsically superior institution for sustaining children and families,” she says. In fact, Stacey says “our needs for both eros and domesticity are at often at odds.” Binding parenting to marriage makes a child’s well- being too vulnerable to “Cupid’s antics.”Instead, she advocates that: A democratic society should encourage dignity, respect, and success for all of the honest, consensual, and responsible modes of living, loving, and caretaking to its citizens diverse. The state should be trying to ensure that citizens can freely enter and sustain supportive relationships and freely exit abusive ones. It has a legitimate interest in promoting responsible, committed care and protection for children and other dependents. I don’t disagree with that, but that doesn’t answer an essential question: who should become parents — everyone, or only those who can prove themselves able to fully take on the responsibilities, regardless if they’re married, single, divorced, gay, straight or polyamorous? Many have joked about the idea that people who want to have kids should be licensed — is that a bad idea? We can’t marry without applying for a license; we can’t hunt, fish, scuba dive, drive, fly, run a business or walk dogs other than our own without getting a license. Shouldn’t we get a license to parent, too? What would be so wrong about insisting individuals who want to raise children — whether they’re single, married, living together, in a civil union or whatever; straight or gay; and whether the child is biological or adopted — take parenting classes, outline a parenting plan, and have to prove him/herself financial responsible before he/she could apply for a parenting license and pop out a baby? Without a doubt, it should be an individual license, not a couples’ license; people make bad partner decisions all the time — why should the kids suffer for that? But if two people who each have a license want to have a baby together, more power to them. The state could encourage that relationship by giving additional incentives for each year that partnership remains together. Of course, this is not a new idea; people have been talking about licensing parents for 3. So why don’t we have licensing yet? As they say, it’s complicated. I’m sure many people would object to any more intrusion into such a private matter. And while the decision to have a baby is indeed private, society pays a huge, huge cost for crappy parenting — everything from crime to abuse to addictions to obesity and related health problems to the poorly educated and unemployable. Why aren’t we holding parents accountable for their bad behaviors? And, of course, the state already deals with some forms of bad parenting, neglect and child abuse. But even the American Academy of Pediatricians argues that we should be doing more. The state should: encourage and support individuals who want to care for children, presume that any couple or individual is capable of adequate child- rearing, and ensure that all adults who are raising children (whether married or not) have the material resources and support necessary to be good parents. Such a policy would (1) set a reasonable minimal threshold for state recognition, (2) be vigilant in identifying cases falling below this threshold, and then (3) either assist or disqualify underperforming arrangements. It would also, appropriately, decouple arguments about legitimate and illegitimate types of relationships from arguments about what is best for children. What do you think we should do to better support children’s needs? Would requiring education and a license create better parents? Do the parents of a child need to be romantic partners? Robot Check. Enter the characters you see below. Sorry, we just need to make sure you're not a robot. For best results, please make sure your browser is accepting cookies. Amazon.com: Dead Names: The Dark History of the Necronomicon (9780060787042): Simon: Books. Amazon Try Prime Books Go. Sign in Your Account Sign in Your Account Try Prime Lists Cart. Lovecraft : Home : His Life : His Writings : His Creations : His Study : Popular Culture. History of the Necronomicon. Download History Of The Necronomicon And Ex Oblivione PDF eBook was an early influence. Intellectually precocious but sensitive, Lovecraft began composing fundamental horror tales by the age of eight, howbeit suffered from. View the manual View update history Read related news View discussions Find Community Groups Share Embed. An index to all references to the Necronomicon in the Cthulhu Mythos stories of H.P. Lovecraft and his friends . History of the Necronomicon, by H. NECRONOMICON: Some Facts About A Fiction is an essay by Magus Peter H. Read on and learn the truth about this controversial tome. Free Drawing Programs. Free Drawing Program #2. Irfanview. I use an image program called Irfanview and I love it, a lot! This was my very first image program and it is so easy to learn and use. Use Irfanview to reduce the size of your drawings or photos or add text over your images, really, there's heaps of things that you can do. It's a good program to start with because it shows you the basics of how most image programs operate, with no huge learning curve. You can move on to more sophisticated programs when you are ready. There are numerous sites with Irfanview tutorials, and each one shows different features. After you download it and you need some help, just scroll down on their home page to find links to tutorials and frequently asked questions. Play with it and see what you can do! Just because these are free drawing programs, it doesn't mean they aren't good quality. On the contrary, they pretty much do everything. Free Drawing Program #4. Microsoft Paint. Paint (formerly Paintbrush for Windows) is a simple graphics painting program that has been included with all versions of Microsoft Windows. It is often referred to as MS Paint or Microsoft Paint. To access it on your computer, click on . My granddaughter loves this program, at 4 years old it kept her occupied for ages. She selects a brush and a color and she has a lovely time creating designs on the canvas. It'll show you what each icon (or symbol) does. It's a good idea to practice with this before you decide to buy a drawing tablet. Best Free Paint Program. It is a nice choice for natural drawing and free-hand artists. Drawing Cartoons Ltd Comics. Offers in-app purchases. Stickman Animator is a program for creating and animating stick figures. Although you can find free drawing software. Xara's drawing program lets you make Flash animations. Some of the other free drawing programs also have this facility. Free Drawing Program #5. Gimp. I haven't had much time to play with this program, but it is very good and also popular. If you want to download Gimp, look for the . These tutorials will show you everything this program is capable of doing. It really is remarkable and so awesome that it is free. Free Drawing Program #6. Artweaver. I have yet to use Artweaver but Michael (a regular visitor to this site) had some fun with it and urged us to try it out. Michael used Artweaver to transform a pencil drawing into color on a piece entitled Country Sunday. There is a free version and a paid version so when you visit the Artweaver website, click on the button to download Artweaver Free. The free version will do most things so have fun playing with it. In Appreciation. Thank you very much to all of the generous people who make these fantastic free drawing programs available to us. Inkscape is professional quality vector. Flexible drawing tools; Broad file. Inkscape is Free and Open Source Software. Free drawing software created a spark inside of me like nothing. Originally popular with manga and comic book. Using Paint.net with a Computer Drawing Tablet - Video Paint.net is another free drawing program that you. Comic Book Creator is an admirable attempt to make comic-book making accessible to the artistically disinclined. Loaded with a wide array of page and panel layouts, but lacking in drawing tools, CBC is aimed at. DrawPlus Starter Edition Free graphic design software. Create bespoke designs, logos, technical. Try SmartDraw's drawing program, the perfect drawing tool for creating all kinds of great-looking drawings, charts, graphs, and illustrations. |
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